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NSC23005 sodium

CAS No. 1796596-46-7

NSC23005 sodium ( NSC 23005 sodium;NSC-23005 sodium;p18-IN-40 )

Catalog No. M12713 CAS No. 1796596-46-7

A novel specific, effective p18 (p18INK4C) inhibitor that can selectively promote HSCs expansion with EC50 of 5.21 nM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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2MG	49	In Stock
5MG	77	In Stock
10MG	105	In Stock
25MG	231	In Stock
50MG	413	In Stock
100MG	592	In Stock
200MG	Get Quote	In Stock
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1G	Get Quote	In Stock

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Biological Information

Product Name

NSC23005 sodium
Note

Research use only, not for human use.
Brief Description

A novel specific, effective p18 (p18INK4C) inhibitor that can selectively promote HSCs expansion with EC50 of 5.21 nM.
Description

A novel specific, effective p18 (p18INK4C) inhibitor that can selectively promote HSCs expansion with EC50 of 5.21 nM; inhibits p18, and then activates CDK4/6, promotes HSCs expansion in both murine and human models; shows no activity in promoting the proliferation of leukemia cells, and no significant cytotoxicity toward 32D cells or HSCs.
Synonyms

NSC 23005 sodium;NSC-23005 sodium;p18-IN-40
Pathway

Angiogenesis
Target

CDK
Recptor

p18INK4C
Research Area

Cancer
Indication

——

Chemical Information

CAS Number

1796596-46-7
Formula Weight

305.33
Molecular Formula

C13H16NNaO4S
Purity

>98% (HPLC)
Solubility

DMSO: 6.4 mg/mL (Need ultrasonic)
SMILES

C1CCC(CC1)NS(=O)(=O)C2=CC=C(C=C2)C(=O)[O-].[Na+]
Chemical Name

Benzoic acid, 4-[(cyclohexylamino)sulfonyl]-, sodium salt (1:1)

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Xie XQ, et al. Sci Rep. 2015 Dec 18;5:18115.

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